European evidencebased guidelines on pancreatic cystic. Ct of serous cystadenoma of the pancreas and mimicking masses. Serous cystadenoma is more common than mucinous cystic neoplasm, with a ratio of about 2. Serous cystadenoma of the pancreas, also referred as microcystic adenoma, is an uncommon type of benign cystic pancreatic neoplasm.
After haemodynamic stabilisation, an urgent abdominal ct scan revealed a large. Cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. Serous cystadenoma of pancreas is a rare benign cystic neoplasm constituting 12% of all exocrine pancreatic tumors and isnt it 1015% of all cystic pancreatic neoplasms. Differential diagnosis of pancreatic serous cystadenoma. Pancreas is an important gland which produces digestive juices as well as insulin and glucagon hormone needed for maintaining optimum level of sugar in the blood. Abstract background the preoperative diagnosis of pancreatic serous cystadenoma sca is important because as a typically benign tumor. Once thought to be rare, cystic neoplasms of the pancreas are being diagnosed with increased frequency because of improvements in pancreatic imaging 14.
If there are no signs and symptoms, then a wait and watch approach has been recommended by some experts, since it is a benign condition. This article is brought to you for free and open access by the jefferson digital commons. Serous cystadenoma article about serous cystadenoma by. Serous cystadenoma of the pancreas is commonly considered to be a benign. Serous cystadenoma sca represents a form of pancreatic cystic neoplasm which accounts for 1015% of pancreatic tumors and is characterized by benign behavior and heterogeneous macroscopic features. Serous cystadenoma of pancreas is a benign tumor of pancreas.
The natural history and malignant potential of serous cystadenomas differ significantly from that of other cystic neoplasms. Management of pancreatic serous cystadenomas advances in. Causes of ovarian serous cystadenoma answers on healthtap. Classification of the adnexal masses histopathology results n % benign masses 45 100 serous cystadenoma 15 33. Ten cases of cystadenoma or cystadenocarcinoma of the pancreas were examined by computed tomography ct. Serous cystadenoma of the pancreas libre pathology. Ct of serous cystadenoma of the pancreas and mimicking. Mcn, serous cystic neoplasm, rare cysts, neoadjuvant treatment, and. Serous pancreatic cystadenomas are benign tumours and most cases are detected incidentally. Microcystic serous cystadenoma of the pancreas is an uncommon pancreatic exocrine neoplasm that morphologically resembles conventional clear cell rcc, in so far as both tumors are characterized. In contrast to some of the other cystforming tumors of the pancreas such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm, serous cystic. Accounts for almost 50% of pancreatic cystic neoplasms. Majority occurs in the body and tail, although 30% of the time they are seen in the head. Serous cystadenoma article about serous cystadenoma by the.
Since 1978, 211 cases have been reported in the literature. The origin and evolution of this disorder remain unclear, but even metastatic cases have an excellent prognosis. There is a recognized strong female predilection m. Benign ovarian cysts are one of the most common gynecological conditions occurring in the adolescent and reproductive age group. Rare presentation of serous cystadenoma as hemorrhagic cyst author. Serous cystadenoma of pancreas is an uncommon form of cystic tumor of pancreas.
Mar 08, 2012 among this group of lesions, the serous cystadenoma is typically asymptomatic. Apr 06, 2017 cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. A patient with a history of a large pancreatic serous cystadenoma sca presented to the emergency department with abdominal pain and haemodynamic shock. Serous cystadenoma definition of serous cystadenoma by. Serous cystadenoma of the pancreas is the most common benign pancreatic neoplasm.
Serous cystadenocarcinoma of the pancreas and serous. Typical and atypical manifestations of serous cystadenoma of. Serous cystadenomas are the most common type of cystic neoplasm of the pancreas 5. Cystadenomas and cystadenocarcinomas of the pancreas ncbi. Magnetic resonance imaging showed a hypervascular mass in the tail of the pancreas of a 72yearold female who presented with mild abdominal pain. Mixed serous cystadenoma with mucinous cystadenoma of the. The pancreatic serous cystadenoma is an epithelial neoplasm that mostly affects women with a slight predominance in the pancreatic head. Pancreatic serous cystadenoma is typically found in women accounting for 74% of cases with a mean age of 58 years 1699 years, and the tumor is usually located at the bodytail of the pancreas. May 11, 2018 how is benign mucinous cystadenoma of pancreas treated. Serous cystadenoma microcystic and oligocystic is relatively rare among pancreatic neoplasms 1, 2. Three cases of pancreatic serous cystadenoma and endocrine. Typical and atypical manifestations of serous cystadenoma. Pancreatic serous cystadenoma is a benign tumour of pancreas.
Computed tomography of cystadenoma and cystadenocarcinoma. A 86year old patient known to have a serous cystadenoma of the pancreas treated conservatively. Serous cystadenoma of pancreas is mainly present in women, especially over the age of 60 years. Serous cystadenoma of the pancreas is a diagnosis being entertained with increasing frequency. Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. This cystic neoplasm is made up of several small cysts spread into a honeycomb like appearance. Jan, 2019 serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst. This is a common benign ovarian tumor diagnosed by microscopic examination.
The first large series of pathologically proven serous cystadenoma was first described in 1978 21. Thus, surgical intervention should be proposed in a minority of patients with serous cystadenoma, and only for those who had uncertain diagnosis after systemic examinations or had symptoms 20, 21. Serous cystadenoma of the pancreas pubmed central pmc. Serous cystic neoplasms of the pancreas although they carry a realistic risk of malignancy, the predominant view is that they never become malignant. Three of the 25 tumours 12% showed a malignant behaviour on histological assessment, whereas two patients with serous cystadenoma 8% revealed an association with ductal adenocarcinoma. Diagnostic criteria, potential for growth or malignancy, and outcomes are not well defined.
The treatment measures available for benign mucinous cystadenoma of pancreas include the following. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun content. Mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%. Serous cystadenoma of the pancreas is commonly consid ered to be a benign. Pdf serous adenomas represent 12% of pancreatic neoplasms and typically are. In all, 106 patients diagnosed with serous cystadenoma were identified. Dec 16, 2019 mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%. Its clinical and pathological recognition as a separate entity from the mucinous cystic neoplasms has been characterised by compagno and oertel 3, 4. Mucinous cystadenoma has considerable malignant potential, estimated to be between 10 and 50%. In fact, once diagnosed correctly through ct scans, mri, eus, fna, serology and blood test studies, observation and routinely reassessment of asymptomatic lesions is indicated thereby avoiding a major operation and resulting morbidity and mortality 1 3. Differential diagnosis of pancreatic serous cystadenoma and. Cystic neoplasms of pancreas are relatively rare tumours that can be divided into serous and mucinous category. The two most common cystic neoplasms of the pancreas are serous cystadenoma and mucinous cystic neoplasms.
Additionally the presenting symptoms are not characteristic. Nowadays, the current management of serous cystadenomas of the pancreas is essentially conservative. Although a lobulated contour is a specific feature of serous cystadenoma, it may be over looked on the initial ct evaluation fig. Serous cystadenoma of pancreas is mainly present in women, especially over the age of.
Vhl associated cases are sometimes patchy, multifocal pancreas 2012. Majority of these tumors have microcystic appearance. All but one showed characteristic findings consisting of both cystic and solid components. Commonly, pancreatic serous cystadenomas are considered to be benign neoplasms, whereas mucinous cystadenomas are thought.
These are uncommon tumors and constitute about 12% of all pancreatic tumors. Between january 1986 and october 1998 25 patients with serous cystic neoplasms of the pancreas were operated at our institution. Figure 1 large amount of free peritoneal air and free fluid alongside with evidence o metastatic liver disease. These tumors are very similar to benign serous cystic neoplasms scns of the pancreas, except that they tend to be larger, are locally invasive, and present distant metastasis. Cystadenomas represented 76% of all primary pancreatic cystic tumors 398522. Serous cystadenoma of pancreas radiology reference article. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more. Serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst.
The histopathologic findings, diagnostic strategy, differential diagnosis, and treatment strategy of these generally benign but sometimes symptomatic lesions are discussed. Jul 14, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. An oligocystic serous cystadenoma appears as a multicystic or lobulated cystic lesion with septation in the head of the pancreas, whereas mucinous cystic neoplasms have smooth contours with or without septation, and intraductal papillary mucinous neoplasms have either a pleomorphic or a clubbed, fingerlike cystic shape. Serous cystadenoma of pancreas occur in adults in the age group of 2590 years, with average age of presentation being 60 years. Although a lobulated contour is a specific feature of serous cystadenoma, it may be over. Pancreatic serous cystadenoma with signs of compression em. Ovarian serous cystadenoma, also less precisely known as serous cystadenoma, is the most common ovarian neoplasm, representing 20% of ovarian neoplasms, and is benign it has a very superficial resemblance to the most common type of ovarian cancer serous carcinoma of the ovary under the microscope. Serous cystadenoma sca of the pancreas, encompassing serous microcystic adenoma sma and serous oligocystic adenoma soa, accounts for 1% to 2% of exocrine pancreatic tumors. Diseasefree survival was defined as the length of time. Complete blood count, liver function test, amylase level, ca 199, cea levels were within normal limits. Serous cystadenomas scas are benign tumors, and serous.
Innumerable small cysts producing a honeycomb appearance were. Herein, we report a case of a solidtype serous cystadenoma of the pancreas which is the 16th case reported worldwide and the first ever reported in greece. How is benign mucinous cystadenoma of pancreas treated. The most common presentation is with numerous small cysts that give a honeycomb appearance microcystic variant, thin septa, and sometimes with a central scar. Distal pancreatectomy was performed by laparotomy and histological and immunohistochemical.
Wed like to understand how you use our websites in order to improve them. We report a case of serous cystadenoma of the pancreas mixed with mucinous cystadenoma. Cystadenomas and cystadenocarcinomas of the pancreas. Rare presentation of serous cystadenoma as hemorrhagic cyst. Resection is generally carried out for symptoms, large size, or the inability to distinguish a serous cystic neoplasm from a mucinous lesion, which has greater. Discussion serous cystadenoma of pancreas is a rare benign cystic neoplasm constituting 12% of all exocrine pancreatic tumors. Distal pancreatectomy was performed by laparotomy and histological and.
Serous cystadenoma of the pancreas is a benign cystic lesion of the pancreas. Serous microcystic cystadenocarcinoma of the pancreas with. Serous cystadenocarcinoma of the pancreas is a rare but wellestablished entity. Large amount of free peritoneal air and free fluid alongside with.
Pancreatic serous cystadenoma with compression of the main. Serous cystadenomata scas are benign entities that historically have been described to constitute 1% of neoplasia from the exocrine pancreas. A 65yearold woman was admitted to our hospital for evaluation of a palpable, elastic, hard mass measuring 6 cm in diameter in the right upper quadrant of the abdomen. Cystic lesions of the pancreas are being identified in increasing numbers, both because of the frequent use of radiography and advances in imaging techniques. Serous cystadenoma sca represents a form of pancreatic cystic neoplasm which accounts for 1015% of pancreatic tumors and is characterized by benign behavior and heterogeneous macroscopic features, although the microscopic structure of pancreatic sca is uniform, the macroscopic feature shows a wide heterogeneity. While serous cystadenoma is the most common of them all, they rarely grow to large sizes unless. Resected serous cystic neoplasms of the pancreas jefferson. Aug 25, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. It is also known as serous microcystic adenoma, 1 and pancreatic serous cystadenoma. It typically occurs in women most tumors do not cause any signs and symptoms, but in some individuals, there may be abdominal pain, indigestion, and loss of appetite due to serous cystadenoma of pancreas. Mixed serous cystadenoma with mucinous cystadenoma of the pa.
The prevalence of cancer among serous cystadenomas is reported to be 3% since the first case reported in the literature in 1989. Radiographic imaging is a potent tool with which to diagnose serous cystadenoma of the pancreas, but limitations exist. The most widely applicable radiographic test at the current time is helical ct scanning with thin cuts through the pancreas, which often can provide assistance in the differentiation between serous and mucinous neoplasms. It is rather clear from the literature that the differentiation between benign and malignant serous cystadenoma both histologically and clinically may be very difficult 911. Serous cystadenoma of the pancreas is a rare lesion thought to be almost invariably benign. The full text of this article is available in pdf format. The risk of malignant transformation seems to be low even in the longterm course 1. Case report open access serous cystadenocarcinoma of. Macrocystic and solid variants have also been described. Pancreas, serous cystadenoma, computed tomography, pancreatic cysts. Typical macroscopic characteristics of serous cystadenoma of the pancreas consist of microcystic mass with a spongelike honeycomb aspect or central scar or both. Serous cystadenoma sca of pancreas accounts for more than half of cystforming neoplasms and has been increasingly recognized with advancement of clinical imaging evaluations.
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